The striker netted in the first-half of the tie to give Arsenal hope of progressing before Anthony Martial restored United’s two-goal lead after the interval.
Aubameyang’s goal may not have made a difference to the result – but the Arsenal forward is now the only Gunners player to hold a bizarre record.
Friday night’s goal now means the former Dortmund man is the first Arsenal player to score on every day of the week in a single season.
Aubameyang bagged a brace on a Monday night in October against Leicester.
Tuesday and Wednesday’s strikes came against Fulham and Brighton respectively, while the 29-year-old has scored two goals in the Europa League this season on a Thursday.
Eight of Aubameyang’s goals this season have been scored on a weekend.
Unfortunately, that odd record won’t win Arsenal their place in the next round of the FA Cup.
And the Gunners suffered a number of injuries during the clash to make matters worse.
Laurent Koscielny and Sokratis Papastathopoulos were both forced off with an ankle problem and suspected broken jaw respectively.
And Unai Emery was concerned in his post-match press conference.
“Our injuries changed our possibility to do something different,” he said.
“When we were 2-1 down we had chances to draw but we didn’t score.
“Sokratis hurt his ankle – I hope not a lot.
“Koscielny is different. It was maybe a break. I hope not but he’s going to the hospital and we’re going to wait.
“We are taking a lot of big injuries, like Hector Bellerin.
“We played a team in a good moment. We lost this match but I’m happy with our work.”