The Premier League sides face last 16 opponents from the Bundesliga and Ligue 1 as they bid to end a seven-year wait for an English champion.
Chelsea were the last side to lift the European Cup and the team they defeated that night, Bayern Munich, are aiming to knock out five-time winners and title hopefuls Liverpool.
Manchester City are favourites to lift the trophy in Madrid come May which would see Pep Guardiola win his third Champions League as a manager.
Holders Real Madrid have won the competition for the last three years but are not fancied to win a fourth having experienced wholesale changes in the last 12 months.
Manchester United v PSG – Tuesday 12th February 8pm
Ole Gunnar Solskjaer faces his sternest test yet as interim manager at Old Trafford when they host the Ligue 1 champions.
Their task has been made easier with Neymar and Edinson Cavani both absent through injury.
Kylian Mbappe will therefore lead the line and he will be opposed by compatriots Paul Pogba and Anthony Martial.
The French duo have reached new heights in the last two months and, alongside Marcus Rashford and Jesse Lingard, give United a genuine chance of progression.
Tottenham v Borussia Dortmund – Wednesday 13th February 8pm
The Bundesliga leaders head to Wembley aiming to avenge the 3-1 defeat they suffered there in last year’s competition.
Now led by Lucien Favre the German side have lost just one of their 21 league games so far this term.
In Tottenham though they take on side who’ve won ten of their last 12 league games including the last four.
Mauricio Pochettino’s side narrowly navigated a challenging group following a 1-1 draw in Barcelona and will hold no fear when they host the 1997 champions.
Liverpool v Bayern Munich – Tuesday 19th February 8pm
A tie that pits five European Cups against five European Cups and gives Jurgen Klopp a chance to settle some old scores.
The German boss welcomes Bayern to his Anfield fortress with his last European meeting against the Bavarians coming in the 2013 Champions League final.
Arjen Robben’s late winner denied then Klopp’s Dortmund that night but the Dutchman is not expected to be fit in time to face the Reds.
The Champions League is Liverpool’s only chance of silverware outside the Premier League and Klopp has proved himself capable of raising his team for the big European occasions.
Schalke 04 v Manchester City – Wednesday 20th February 8:00pm
The current Premier League champions have been handed the most favourable draw of all the English sides.
City will travel to Gelsenkirchen – the scene of Jose Mourinho’s first Champions League success – as they bid to reach the quarter-finals.
Last term Guardiola’s side didn’t offer enough in Europe and they will be eager to make inroads on the European stage.
A sole semi-final in 2016 remains their best ever showing and their Catalan manager will be aiming to at least match the achievement of his predecessor Manuel Pellegrini.