United crashed out of the FA Cup at Molineux, falling to a 2-1 defeat to Wolves thanks to second half goals from Raul Jiminez and Diogo Jota.
And things went from bad to worse when the travelling side were reduced to ten men in the 82nd minute.
Lindelof was shown a straight red by referee Martin Atkinson after a heavy challenge on goalscorer Jota.
But VAR referee Chris Kavanagh swiftly acted and relayed information to his counterpart, telling him to revoke the red and award a yellow card instead.
Lindelof remained on the pitch but couldn’t help his side turn the tide.
United fans wanted VAR to be used earlier in the match after Jonny Otto appeared to use him arm to block a shot from Diogo Dalot.
But Atkinson decided against checking the technology in the first half.
In this evening’s other FA Cup clash, Man City were lucky VAR was not being used at the Liberty Stadium.
The Premier League champions nearly crashed out of the competition to Swansea before a late comeback.
City were awarded a controversial penalty after Raheem Sterling fell in the penalty area.
And Sergio Aguero headed home the winner in the closing stages but was stood in an offside position.
VAR wasn’t in use during the clash due to the Liberty Stadium not being a Premier League stadium.
Speaking after the game, Pep Guardiola said: “You have to ask the authorities why VAR is not here.
“All around it is there, but here it is not.
“If it’s not a penalty and it’s also offside, I am sorry. I don’t like to win games when decisions are wrong. It’s not easy.”