Lionel Messi is looking to add to his 22 goals against English opposition in the Champions League.
Premier League outfits have fared worse than teams from any other league against the 31-year-old.
Messi’s 22 goals include hat-tricks against Arsenal in 2010 and Manchester City in 2016.
Messi has hit the back of the net 108 times in Europe with over 20% of those strikes against English teams.
The Argentine has scored against United in each of the Champions League finals in which he has played against them, but they are his only two goals against the Red Devils.
Arsenal have been the Barcelona star’s favourite opposition with the Gunners seeing him score nine goals against them.
Messi has scored six times against Manchester City – now led by his former mentor Pep Guardiola.
Chelsea and Tottenham are his other victims meaning Liverpool are the only English side to face the five-time Ballon d’Or winner and keep him scoreless.
News from ahead of tonight’s clash include:
Messi could also become just the third player to score a Champions League hat-trick against the Red Devils if he were to score three tonight.
Ronaldo notched a treble for Real Madrid in 2003 while former Stoke City forward Tuncay did the same for Fenerbahce 18 months later.
United fans have not seen their team keep a clean sheet since their goalless draw with Liverpool on February 24 nine games ago.
Luke Shaw deflected Luis Suarez’s header into his own net at Old Trafford six days ago which was the Catalan’s 20th goal in Europe this season.
Ole Gunnar Solskjaer will lead his team tonight in the stadium where he scored the winning goal in the Champions League final two decades ago.
But the Norwegian is instead looking to recall wins on the road against Juventus and PSG this season to install belief into his team tonight.