The Barcelona hitman led his side to a 4-0 aggregate win over Manchester United this week, netting two in the process.
His brace means Messi has now scored 24 goals against English clubs in the Champions League.
And that is officially more than some Premier League stars of past and present.
Tottenham forward Harry Kane has only scored 22 times against England’s top teams.
While former Premier League stars Wayne Rooney and Robin Van Persie only notched 20 and 18 respectively during their time in the division.
Chelsea star Eden Hazard, who joined Stamford Bridge in 2012, has scored 26 at present.
Meanwhile, United striker Romelu Lukaku has failed to score against any of the Premier League big boys this season.
Two players who have netted more than Messi against the big six are Leicester’s Jamie Vardy (29) and Sergio Aguero of Manchester City (43).
The Barcelona icon has netted a whopping nine against Arsenal, six against Man City and four against Manchester United.
His other five have been while facing Tottenham and Chelsea.
Speaking after Messi’s Nou Camp masterclass on Tuesday evening, United boss Ole Gunnar Solskjaer said: “I have to say Lionel Messi is top quality and he was the difference of course.
“At 2-0 straight after it was game over.
“He’s different class.
“He and Cristiano Ronaldo are the best players of the last decade, everyone agrees on that one.
“Messi showed his quality.”
Messi will have the chance to net his first ever goal against Liverpool in the semi-final, should the Reds progress past Porto this evening.