The Red Devils welcome their local rivals to Old Trafford this evening for a clash which will go a long way to deciding the outcome of the title race and the battle for the top four.
United need to bounce back after their 4-0 humbling at Goodison Park on Sunday afternoon.
And Ole Gunnar Solskjaer has hinted he will wring the changes this evening to prepare his side for City’s attacking threats.
But United officials have also been preparing themselves, putting measures in place to ensure rival fans don’t clash before or during the game.
According to the Daily Mail, Old Trafford chiefs have this week installed 6ft fences outside the away turnstiles in the hope it will prevent any fan clashes on the concourse behind the away section.
That particular part of the stadium has been a hotbed for clashes in recent seasons, which spurred officials into action.
The fences have been in place against European sides and have worked to prevent opposite sets of fans from fighting.
Chief Superintendent Graeme Openshaw, who will be overseeing Greater Manchester Police’s operation, said: “We are looking forward to another huge footballing occasion for Manchester.
“We’ve been working closely with both clubs to ensure that everyone can enjoy the game in a safe environment.”
Speaking about matters on the pitch, Solskjaer this week hinted he will drop underperforming stars after Sunday’s Everton defeat.
“Of course there will be consequences,” the Norwegian told Sky Sports.
“We’re not going to see the same team.
“We had a plan before the (Everton) game how we’re going to look against City anyway and some decisions would have to wait.
“We had a plan anyway and those two plans (Everton and City) weren’t the same.”