The Greek star was rumoured to be unsettled at the Serie A club last week, amid reports he was being eyed by a number of European clubs.
Italian outlet CalcioMercato set tongues wagging in Manchester by revealing that the Red Devils were in ‘pole position’ to sign Manolas this summer.
But the central defender has appeared to rule out an imminent move by insisting he is happy in Rome.
“I have my life in Rome and I’m happy there. My life is very simple,” he told Il Turista.
“I spend most of my free time at home with my family. I like it. I approach my career like I do life: I can go high and get great results, but I always have to keep my feet on the ground and remember where I started.
“Football, like life, gives you nothing. You have to fight to reach your objectives. My grandfather gave me my first pair of boots when I was little.
“My mother said that my first word was ‘objective’ while holding a football, not ‘mum’ or ‘dad’.
“Something inside me made me understand right away that I’d become a footballer, although I did very well at school.”
Manolas has previously stated his interest in both Real Madrid and Barcelona but may be offered a similar wage packet should he eventually move to Old Trafford.
United are desperate for a new central defender and are keen on Manolas due to €36m (£30.8m) release clause.
This is significantly cheaper than two of Ed Woodward’s other reported targets – Raphael Varane and Kalidou Koulibaly.
Starsport also understand Leicester’s Harry Maguire is a target at present.
Varane is said to be unhappy at Madrid and seeking a new challenge.
But he would command a world-record fee should he leave the Bernabeu.
Koulibaly is also being valued at around £150m as he continues to attract interest at Napoli.
The Senegal star has been a target of United’s for a while.