This is the first time the two rivals have met since a League Cup third-round tie in 2011 at Elland Road, which Sir Alex Ferguson’s side won 3-0.
Ole Gunnar Solskjaer’s side recorded a 2-0 win over Perth Glory on Saturday as James Garner and Marcus Rashford found the back of the net.
Today’s game against a stronger opposition will test Solskjaer’s men while the Norwegian will have to up his own game coming up against the experience of Marcelo Bielsa.
Starsport predicts three key talking points that could emerge from today’s encounter.
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Man Utd 2-0 Leeds – LATEST SCORE
– Mason Greenwood scores opener on seven minutes
– Marcus Rashford doubles their lead before the half hour mark
Manchester United XI: Romero, Wan-Bissaka, Lindelof, Bailly, Rojo, McTominay, Pogba, Greenwood, Mata, James, Rashford.
Subs: Pereira, Dalot, Jones, Smalling, Tuanzebe, Young, Andreas Pereira, Garner, Gomes, Matic, Chong, Lingard, Martial.
Leeds XI: Casilla, Dallas, Cooper, Berardi, Douglas, Phillips, Forshaw, Harrison, Hernandez, Roofe, Bamford.
Subs: Miazek, Hosannah, Oduor, Bogusz, Stevens.
Paul Pogba watch
The Manchester United midfielder has made all the headlines this summer with his agent Mino Raiola admitting a transfer is on the cards.
Solskjaer has been left in a difficult position but has publicly backed the Frenchman to stay at Old Trafford.
Pogba bas remained coy on his own future since confessing he could seek a ‘new challenge’ earlier this summer.
And the 26-year-old’s display today could determine exactly where his head is at.
Will he stay professional, setting an example to his younger team-mates and deliver the type of performance he showed during the France World Cup last year?
Or could a disappointing display signal his head is elsewhere with Real Madrid and Juventus circling? Over to you, Paul.
New signings watch
Sadly for United fans it’s still just the two new signings to keep an eye on with Harry Maguire yet to leave Leicester.
But Daniel James and Aaron Wan-Bissaka were the stars of the show against Perth Glory.
Former Swansea winger James had fans excited over his incredible pace on his debut with Solskjaer looking to create a fitter squad with a higher intensity style of play this year.
As for Wan-Bissaka, supporters are already getting to see why he was nicknamed ‘The Spider’ at Crystal Palace with his long legs helping him execute the perfect slide tackles.
Today’s match will prove a lot tougher test for United’s new boys and the added rivalry between the two clubs should make for a fiery atmosphere.
Kalvin Phillips tester
Kalvin Phillips has been the name on Aston Villa’s shortlist for some time but can he cut it in the Premier League?
We should find out this afternoon when the midfielder comes up against the likes of Juan Mata and Pogba.
Leeds are in talks with the 23-year-old over a new deal but with Villa keen to offer him a way out Phillips is yet to commit his future.
Phillips, who can also play in central defence, made 46 appearances last season as Leeds finished third in the Championship, but were then beaten by Derby in the play-off semi-finals.