The French champions bounced back from their first league defeat of the season away at Lyon to claim a narrow 1-0 win over Bordeaux on Saturday.
It has been a pretty comfortable defence of their title so far, with Lille 10 points behind in second place.
And the gap could become even bigger when PSG play their two games-in-hand.
Next up for them, though, is a trip to Old Trafford in the Champions League tonight.
“Edinson Cavani, Neymar and Thomas Meunier are all unavailable”
Tuchel has a number of players missing out through injury.
Edinson Cavani, Neymar and Thomas Meunier are all unavailable, while Adrien Rabiot has been dropped to the under-23 squad following his refusal to sign a contract extension at the Parc Des Princes.
In goal, Gianluigi Buffon should get the nod.
Thilo Kehrer, Thiago Silva, Presnel Kimpembe and Juan Bernat are likely to make up the back four.
One player who will be fit is Marco Verratti, who started in Saturday’s win over Bordeaux after recovering from an ankle injury.
The Frenchman is expected to partner Marquinhos in the centre of midfield, sitting behind an attacking-midfield trio consisting of Dani Alves, Julian Draxler and Angel Di Maria.
And leading the line should be none other than Kylian Mbappe.
Tuchel’s men are taking on a United side in a rich vein of form.
Caretaker boss Ole Gunnar Solskjaer has guided the Red Devils to 10 wins out of 11, with his latest victory a 3-0 triumph away at Fulham.
The Norwegian is yet to suffer defeat in the Old Trafford hot-seat.
Tonight’s match is set to kick off at 8pm.